Pathogenesis of Ulcerative Colitis Based on Network Pharmacology and New Therapeutic Targets

Abstract

Ulcerative colitis (ulcerative colitis) is a kind of intestinal inflammatory disease with easy recurrence and long course. Modern medicine does not have a clear understanding of its pathogenesis, and there are no specific drugs to treat it in the world. Therefore, by analyzing, summarizing and summarizing the possible pathogenesis of the disease in existing studies and combining with network pharmacology research, this paper provides references for exploring the pathogenesis of ulcerative colitis and provides ideas for finding new therapeutic targets. While summarizing the literature research on ulcerative colitis in the past five years, combined with the relevant literature and knowledge of network pharmacology, it is believed that ulcerative colitis is mainly related to genetic, immune, microbial, diet, infection, environment and other factors internationally. In the treatment of ulcerative colitis, nf-kappa signaling pathway, tlr4-m y8-nf-kappa signaling pathway and pi3k-akt-mtor signaling pathway play a key role. Therefore, in the treatment of ulcerative colitis, IKK, kappa kappa, MyD88, TAK1, and nf-kappa can be regarded as new therapeutic targets, so as to have a significant effect on ulcerative colitis.