Preparation and Characterization of the Solid Dispersion Quercetin with Phospholipid

Abstract

Quercetin, a typical flavonoid occurring in many herbs, has wide range of pharmacological activities. However, its limited lipid solubility restricts its bioavailability. In this paper, the solid dispersion of quercetin with phospholipid was prepared by solvent evaporation. The physical characterizations of its as well as corresponding physical mixtures were studied by Scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), Differential scanning calorimetry (DSC), and X-ray powder diffraction (XRD), which revealed the changes in solid state during the formation of dispersion and justified the formation of amorphous phase. Solubility of quercetin in dispersion and free quercetin were also studies between n-octanol and aqueous solution with various pH values. It was showed that apparent oil/water partition coefficient increased significantly after forming solid dispersion, which may aid to improve the bioavailability and reduce dose of the drug.