Impact of Five Organic UV Filters on the Multixenobiotic Resistance Mechanism of Human Embryonic Lung Fibroblasts

Abstract

Organic UV filters continuously accumulate after entering the environment, thus posing potential ecological and health risks. The impact of five organic UV filters, namely BP-3, BP-4, OC, EHMC, and BM-DBM, on the multixenobiotic resistance (MXR) mechanism in human embryonic lung fibroblasts (MRC-5) was investigated to identify the toxic effects of inhaled UV filters on human health. Results showed that OC exerted a more significant inhibitory effect on the transport proteins of MRC-5 cells than the chemical sensitizer VER. Moreover, inhibition times significantly increased with the increasing exposure concentration of UV filters. BM-DBM exerted a significant inhibitory effect at exposure concentrations of 10 and 100μmol/L. The results of this study provide powerful scientific basis for the investigation of the impact of UV filters on the MXR mechanism of human cells at the molecular level.